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 Breast Cancer


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Advances in the Diagnosis and Management of Breast Cancer

In 1940, the lifetime risk (to age 85) of a woman developing breast cancer in 1940 was 5%, or 1 in 20. Today, nearly 65 years later, the risk is 12.6%, or 1 in 8. In women 40 to 49 years of age, there is a 1 in 66 risk of developing breast cancer comp...


An Overview of Breast Reconstruction

Reconstructive plastic surgery for breast cancer is performed to replace skin, breast tissue, and the nipple removed during mastectomy. The amount of missing tissue varies with each mastectomy. Factors contributing to the amount of tissue removed incl...


Anastrozole (Arimidex)

Common brand name: Arimidex Why is this drug prescribed? Anastrozole is a hormonal treatment used to treat breast cancer. Anastrozole lowers serum estrogen levels and is commonly used in postmenopausal women How and when should Anastrozole be use...


Anatomy of the Breast

Each breast has 15 to 20 sections, or lobes, that surround the nipple, like spokes on a wheel. Inside these lobes are smaller lobes, called lobules. At the end of each lobule are tiny "bulbs" that produce milk. These structures are linked toge...


Arimidex, Femara and Aromasin

There is a new group of drugs that is being recommended for use in postmenopausal women with advanced breast cancer. The drugs, Arimidex (anastrozole) and Femara (letrozole), are called aromatase inhibitors (AIs). How do these drugs work? Aromatase...


Assessing Your Risk of Inherited Disease

Are you at risk for a certain disease? It's a question we've all pondered at one time, says Brian Clark, Ph.D., M.D., director of the Cleveland Clinic Cancer Center Medical Genetics Program. For some, the answer can be found within their genetic herit...


Beating Breast Cancer Involves Understanding the Treatment Options

As much as a woman tries to brace herself for the news, a diagnosis of breast cancer can be traumatic. And at the very time a woman needs to be clearheaded, there may be only fog. Not surprisingly, it is not uncommon for some women to rush into tr...


Breast Biopsy

What is a biopsy? A biopsy is the removal of cells or tissue from a suspicious mass. The tissue or cells are then examined under a microscope to detect cancer cells. A biopsy may be performed when an abnormal breast change is found during a mammogram, ...


Breast Cancer Detection and Treatment

Breast cancer affects 180,000 women each year, and 46,000 of them die from this disease. Unfortunately, advanced or metastatic breast cancer is not curable. Therefore, emphasis must be directed toward early detection. Early detection of breast cancer ...


Breast Cancer and the Internet

Over the past several years, the Internet has become an important resource for information gathering. This exciting new technology has enormous potential to inform and educate the public about health and medical care. However, the Internet is also rife ...


Breast Cancer During Pregnancy

Breast cancer is the most common cancer in pregnant women and tends to affect women in their mid-thirties. Although only about 1 in every 1,000 pregnant women get breast cancer, the disease can be devastating to both the mother and her child -- so it is...


Breast Cancer Glossary

Adjuvant therapy - Treatment provided in addition to the primary treatment Anemia - A condition that occurs when there is not enough hemoglobin in a person’s blood. Hemoglobin is a substance in the red blood cells that enables the blood to transport oxy...


Breast Cancer in Men

Men don't have breasts. How can they get breast cancer? Even though men do not have breasts like women, they do have a small amount of breast tissue. In fact, the "breasts" of an adult man are similar to the breasts of a girl before puberty,...


Breast Cancer in Young Women

Younger women generally do not consider themselves to be at risk for breast cancer. Only 5 percent of all breast cancer cases occur in women under 40 years old. However, breast cancer can strike at any age, and all women should be aware of their perso...


Breast Cancer Q&A: Lifetime Risk

What is my lifetime risk of developing breast cancer? Today, approximately 1 in every 8 women in the United States will develop breast cancer in her lifetime. The 1 in 8 figure means that, if current rates stay constant, a female born today has a 1 ...


Breast Cancer Q&A: Cancer Pain

I have metastatic breast cancer and often have a lot of pain. Is there any way I can manage this pain? You are not alone; about 90 percent of patients with advanced cancer say pain is the most distressing symptom of their disease. The good news is tha...


Breast Cancer Q&A: Second Opinion

My doctor found a suspicious mass on my mammogram that he thinks is cancerous. I want to get a second opinion. How can I go about this? When abnormal tissue is found during a mammogram or an exam, a small sample of cells or tissue from the affected ar...


Breast Cancer Q&A: Timing of Reconstruction

What are my options if I decide not to have immediate breast reconstruction after my mastectomy? After your mastectomy, you may choose to wear external breast forms or pads or make no attempt to alter your appearance. It is also possible to have reconst...


Breast Cancer Quiz: What’s Your Risk?

1. My mother and sister have both been diagnosed and treated for breast cancer. Does this mean I will get breast cancer too? A. Yes B. No C. Maybe C - Your risk is increased by two or three times that of the general population, and you are at higher ...


Breast Cancer Recurrence

When and where do recurrences occur? Breast cancer can recur at any time, but most recurrences occur in the first three to five years after initial treatment. Breast cancer can come back as a local recurrence (in the treated breast or near the mastect...


Breast Cancer Reference List

CD-Rom The Breast Cancer Lighthouse Gold Standard Multimedia, Inc., Michigan State University To order: 1-800-375-0943 Books A Breast Cancer Journey By Experts at the American Cancer Society American Cancer Society ISBN: 0944235506 Spir...


Breast Cancer Resources

American Cancer Society Breast Cancer Network 1599 Clifton Road, NE Atlanta, GA 30329 1-800-227-2345 or (404) 320-3333 www2.cancer.org/bcn Best Web Sites on Breast Cancer http://darkwing.uoregon.edu/`jbonine/bc_sources.html Breast Cancer and Environ...


Breast Cancer Risk

In 1940, the lifetime risk of a woman developing breast cancer was 5%, or one in 20. In 1997, that risk was estimated at 12%, or one in eight. In many cases, it's not known why a woman gets breast cancer. In fact, 60% of all women with breast cancer hav...


Breast Cancer Risk Assessment

Although scientists have been able to identify risk factors that increase a woman's chance of developing breast cancer, the exact causes are not known. Breast cancer is the most common type of cancer in American women. Over the past 50 years, the number...


Breast Cancer Surgery

Breast-sparing techniques Once breast cancer is detected or diagnosed, treatment plans need to be made to reduce the chance of the cancer returning in or outside of the breast. The goal of surgery is to remove localized cancer (cancer that hasn’t spread...


Breast Cancer: Am I at Risk?

More than ever before, women are taking an active part in their breast health. At the center of this change is our growing concern and understanding of breast cancer, the second most common form of cancer among women in the United States. What is b...


Breast Cancer: An Overview

What is breast cancer? Cells in the body normally divide (reproduce) only when new cells are needed. Sometimes, cells in a part of the body grow and divide out of control, which creates a mass of tissue called a tumor. If the cells that are growing o...


Breast Cancer: Hormonal Therapy (Q&A)

What is hormonal therapy for breast cancer? If lab tests show that your tumor depended on your natural hormones to grow, it will be called estrogen-receptor-positive or progesterone-receptor-positive. This means the tumor will continue to grow when th...


Breast Cancer: Local Treatment Options

What is breast cancer? Breast cancer is defined by an abnormal increase in the number of cells within the milk ducts and lobules of the breast. Eventually these abnormal (cancer) cells can break out of the ducts or lobules into normal surrounding breast...


Breast Cancer: Protecting Fertility

In many cases, treatment for breast cancer involves chemotherapy, radiation therapy, or a combination of the two. These treatments can affect your reproductive system and, as a result, your fertility. Chemotherapy is the use of drugs to kill cancer ce...


Breast Examination After Treatment for Breast Cancer

After treatment for breast cancer, it is especially important for a woman to continue to do a monthly breast examination. Regular examinations will help you detect local recurrences. Early signs of recurrence can be noted in the incision area itself, th...


Breast Health

Screening for breast cancer There is no doubt that the best chance for curing breast cancer is through early detection. Early detection relies on a program of screening, which involves breast self-examination (BSE), physician examination, and mammogra...


Breast Self Exam

What is breast self exam? Breast self exam is a way a woman can examine her breasts to look for changes (such lumps or thickenings) that may signal breast cancer. When a woman detects breast cancer in its early stages, she greatly improves her chances f...


Breast Ultrasound

In ultrasonography, or ultrasound, high-frequency sound waves, inaudible to the human ear, are transmitted through the breast. The echoes are recorded and transformed into video or photographic images. Ultrasound images help in the diagnosis of a wide r...


Cancer Answers: Massage for Breast Cancer Patients, Coping With Cancer Recurrence

When you or someone you love has cancer, you want answers to all your questions – big or small. The Cleveland Clinic’s "Cancer Answer Line" is a toll-free hotline staffed by registered nurses Monday through Friday, 8:30 a.m. to 4:30 p.m. EST...


Chemoprevention

Major Studies Look at the Role of Drugs and Food in Preventing Cancer "An ounce of prevention...." begins the well-worn saying, but in the case of cancer it seems a pound of cure is still the best hope. That may change as researchers study t...


Chemotherapy for Breast Cancer

What is chemotherapy? In cancer treatment, chemotherapy refers to the use of drugs whose main effect is either to kill or to slow the growth of rapidly multiplying cancer cells. Chemotherapy often includes using a combination of drugs, since this appr...


Clinical Breast Examination

A breast examination is an important part of routine physical checkups. How often should I have a clinical breast exam?A breast physical examination by a health care provider (such as your family physician, nurse, or gynecologist) should be performed at...


Composite Breast Reconstruction

Reconstructive plastic surgery for breast cancer is performed to replace skin, breast tissue and the nipple-areolar complex removed during mastectomy. In general, the nipple-areolar complex is removed during any mastectomy operation because it is breast...


Determining Your Breast Cancer Risk

What is breast cancer? In breast cancer, a cell can divide (reproduce without control), forming a malignant tumor. This most commonly occurs in the milk duct, but can also occur in the lobule. Breast cancer facts Lifetime risk for U.S. women is 1 ...


Do Birth Control Pills Cause Breast Cancer?

Since the early 1960s, oral contraceptives have become the most popular and one of the most effective forms of birth control used in the U.S. But an association between estrogen and an increased risk of breast cancer has led to a continuing debate abo...


Doctors Who Treat Breast Cancer

Selecting a doctor to treat your breast cancer may be one of the most important decisions you will ever make. Your primary care physician may refer you to one or more specialists. These specialists include surgeons, medical oncologists, plastic surgeo...


Ductal Lavage

Most breast cancers (about 95 percent) develop in specialized cells called epithelial cells that line the milk ducts of the breast. Each breast has 6 to 9 separate ducts, which function independently of each other. Cancer that begins in one duct may b...


Emotional Aspects of Breast Cancer

Facing a breast cancer diagnosis can be overwhelming. Your stress levels may skyrocket. You may worry about finances and about your body image. And you may be asking yourself difficult questions, such as whether to write a living will. With education ...


Follow-Up Care After Breast Cancer Surgery

Please note: These are general guidelines and may not be applicable to every patient. Always follow your doctor’s specific instructions for care after surgery. Drain careYou may be discharged from the hospital with an external drainage device in place....


Genetic Testing for Risk of Breast and Ovarian Cancer

What is my risk for developing breast or ovarian cancer?Women in the United States have a 1-in-10 risk of developing breast cancer and a 1-in-55 chance of developing ovarian cancer in their lifetime. Certain factors increase this risk. Women who have gr...


Hormone Replacement Therapy and Breast Cancer

Hormone replacement therapy (HRT) is a treatment program in which a woman takes estrogen and progestin (a synthetic form of progesterone) to relieve menopause symptoms. HRT also reduces a woman’s risk for osteoporosis and other conditions that become mo...


Lymphedema

What is lymphedema? Lymphedema is an abnormal buildup of fluid that causes swelling, most often in the arms or legs. The condition develops when lymph vessels or lymph nodes are missing, impaired, damaged, or removed. There are two types of lymphedem...


Men and Breast Cancer: Q&A

I didn’t think men could get breast cancer, but my husband has just been diagnosed. What can we expect for his treatment? Breast cancer can affect men, although it is rare. There is a one in 1,000 or 1 percent lifetime risk of breast cancer in men. Al...


Menopause: Detection and Prevention of Breast Cancer

Menopause itself is not associated with an increased risk of developing cancer. However, the rates of many cancers, including breast cancer, do increase with age. In addition, some of the drugs used to manage menopausal symptoms may increase or decrea...


Minimally Invasive Breast Biopsy

Lumps or masses in the breast are not unusual, and most of them are not cancerous. Some breast masses can be felt during a breast exam. Others are detectable only by mammogram-breast X-ray. How a mass is detected does not determine whether it is cancero...


MRI and Breast Cancer

Magnetic resonance imaging (MRI) is a test that produces very clear pictures, or images, of the human body without the use of X-rays. MRI uses a large magnet, radio waves, and a computer to produce these images. MRI to diagnose breast cancer MRI may be...


New Mastectomy Technique Preserves Normal Breast Appearance

Cleveland Clinic physicians have developed a new mastectomy technique that leaves the nipple intact, allowing for a more natural-looking breast reconstruction. "The response that we are getting from patients to this surgery is the most overwhelm...


Preventive Breast Cancer Surgery

In hopes of avoiding cancer, some high-risk women elect to have both breasts surgically removed, a procedure called bilateral prophylactic mastectomy. The surgery would remove all breast tissue which potentially could develop breast cancer. Preventive b...


Questions to Ask Your Doctor

If you need a biopsy: What type of biopsy will be performed and why? How long will the biopsy procedure take? Will I be awake? Will it hurt? How soon will I know the results? If I do have cancer, who will talk to me about the treatment? When?...


Radiation Therapy for Breast Cancer

What is radiation therapy?Radiation therapy is a form of cancer treatment that uses high levels of radiation to kill cancer cells or keep them from growing and dividing — while minimizing damage to healthy cells. When used for breast cancer treatment, r...


Reconstructive Breast Surgery Without Implants

Implant-free options for breast reconstructionAfter undergoing a mastectomy, a woman may choose to have her breast reconstructed using her own body tissue through what is commonly known as a flap procedure. This operation involves moving healthy tissue ...


Sentinel Node Biopsy

Sentinel node biopsy is a relatively new way of pinpointing the first few lymph nodes into which a tumor drains (called the "sentinel" nodes). This helps doctors remove only those nodes of the lymphatic system most likely to contain cancer cel...


Stages of Breast Cancer: Questions and Answers

What are the different stages of breast cancer? Early stage breast cancer is when the disease is localized to the breast and lymph nodes. (Lymph nodes are glands that are part of a system that helps the body fight infections). Stage 1 breast cancer i...


STAR Clinical Trial

The Cleveland Clinic is taking a closer look at breast cancer prevention. The Cleveland Clinic is participating in STAR, a clinical trial comparing the effectiveness of tamoxifen with raloxifene for breast cancer prevention. Tamoxifen is a drug that has...


Study Finds Nipple-Sparing Mastectomy Is A Reasonable Option For Some Women

Research conducted at The Cleveland Clinic is challenging the long-held belief that nipple-sparing surgery is not a reasonable option for women undergoing total breast removal. Clinic researchers concluded that carefully screened patients may have the o...


Tamoxifen and Breast Cancer

What is tamoxifen? Tamoxifen (Nolvadex) is a medication in pill form that has been used for 25 years to treat breast cancer in women and men. Tamoxifen is one of the most common hormonal therapy drugs. It has been shown to decrease the chance of recurr...


The Cleveland Clinic Breast Program: Why We’re Different

The Cleveland Clinic Breast Program is different and special because it follows the Cleveland Clinic multidisciplinary approach to medical care. The program serves as a centerpiece; a glowing example of how teams of specialists from all disciplines can ...


The Diagnosis is Breast Cancer

What is breast cancer?Breast cancer is a condition in which breast cells grow abnormally and divide without control or order. Breast cancer is the most common form of cancer in women. Early detection and prompt treatment help many women live long, full ...


The Future of Breast Cancer Treatment

Breast cancer continues to be a major concern. Epidemiological cancer data for the United States continue to show an increase in the number of breast cancers every year. In spite of this increase, the mortality for breast cancer is beginning to decline ...


The Genetics of Breast Cancer

Women with a genetic risk for breast cancer account for five to 10 percent of all women with the disease. Having a first-degree relative (mother, sister, daughter) with breast cancer poses the greatest risk to other female members of the family...


The Mammography Debate

Earlier this year, a study by an independent panel of researchers sparked an international debate about the effectiveness of mammograms in preventing breast cancer deaths. Despite the controversy, mammograms still represent an important screening too...


The Role of Ethnicity and Race in Breast Cancer Risk

Breast cancer is one of the most common cancers affecting American women, and is second only to lung cancer as a leading cause of cancer death in women. The number of breast cancer cases (incidence) has been on the rise during the past 20 years, while t...


The  Cleveland Clinic Breast Cancer Screening Guideline

Overview 1. The lifetime risk (to age 85) of a woman developing breast cancer in 1940 was 5 percent or 1 in 20; the risk is now 12.6 percent or 1 in 8. In women 40 to 49 years of age, there is a 1 in 66 risk of developing breast cancer compared with ...


What is the Benefit of BRCA Genetic Testing?

At-risk families can take blood tests to screen for mutations in the BRCA genes. However, genetic testing is done only when definitely indicated by a personal or a strong family history. Genetic testing may also be used to determine if a woman who has a...


What You Need to Know About Tamoxifen

Common brand name: Nolvadex Why is this drug prescribed? Tamoxifen is an antiestrogen drug that blocks the effect of the hormone estrogen. It may be used to treat breast cancer in men or women or to reduce the chances of developing breast cancer in...







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